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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/122/06/0819-0832

    • Keywords

       

      Multi component reaction; 3-cyanoacetyl indole; malononitrile; pyridine synthesis; antiinflammatory activity; analgesic activity.

    • Abstract

       

      A simple protocol for the efficient preparation of 2-($1H$-Indol-3-yl)-6-methoxy-4-arylpyridine-3,5-dicarbonitrile has been achieved through one-pot multi-component reaction under reflux condition. These compounds showed a good anti-inflammatory activity. Also a series of bis-Hantzsch dihydropyridine derivatives were synthesized and they exhibit analgesic activity.

    • Author Affiliations

       

      Prakasam Thirumurugan1 S Mahalaxmi1 Paramasivan T Perumal1

      1. Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020

    • Dates

       
      Published
      November 2010
      Manuscript received
      24 November 2009
      Manuscript revised
      27 May 2010
      Accepted
      25 June 2010

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