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    • An asymmetric route to 2,3-epoxy-syn-1,4-cyclohexane diol derivatives using ring closing metathesis (RCM)

      Soumitra Maity Subrata Ghosh

      Full Papers Volume 122 Issue 6 November 2010 pp 791-800

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/122/06/0791-0800

    • Keywords

       

      Asymmetric synthesis; epoxides; metathesis; Michael addition; natural products.

    • Abstract

       

      An asymmetric route for the synthesis of highly functionalized 2,3-epoxy-syn-1,4-cyclohexane diol derivatives present in some polyketide natural products has been developed. The key step involves RCM of an appropriately constructed 1,7-dienol derived from D-mannitol to cyclohexane-1,4-diol followed by its stereoselective epoxidation.

    • Author Affiliations

       

      Soumitra Maity1 Subrata Ghosh1

      1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032

    • Dates

       
      Published
      November 2010
      Manuscript received
      16 August 2010
      Accepted
      29 October 2010

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