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    • Keywords


      Benzotriazoles derivatives; antibacterial activities; crystal structure; structure-activity relationship.

    • Abstract


      A series of benzotriazole derivatives (compounds 1-27) were synthesized, and 24 (compounds 1-5, 9-27) of which were first reported. Their chemical structures were confirmed by means of 1H NMR, IR and elemental analyses, coupled with one selected single crystal structure (compound 1). All the compounds were assayed for antibacterial activities against three Gram positive bacterial strains (Bacillus subtilis, Staphylococcus aureus and Streptococcus faecalis) and three Gram negative bacterial strains (Escherichia coli, Pseudomonas aeruginosa and Enterobacter cloacae) by MTT method. Among the compounds tested, most of them exhibited potent antibacterial activity against the six bacterial strains. Most importantly, compound 3-benzotriazol-1-yl-1-(4-bromo-phenyl)-2-[1,2,4]triazol-1-ylpropan-1-one (19) showed the most favourable antibacterial activity against B. subtilis, S. aureus, S. faecalis, P. aeruginosa, E. coli and E. cloacae with MIC of 1.56 𝜇g/mL, 1.56 𝜇g/mL, 1.56 𝜇g/mL, 3.12 𝜇g/mL, 6.25 𝜇g/mL and 6.25 𝜇g/mL, respectively.

    • Author Affiliations


      Jun Wan1 2 Peng-Cheng Lv1 Na-Na Tian2 Hai-Liang Zhu1

      1. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu 210093, P.R. China
      2. Key Laboratory of Eco-chemical Engineering, Ministry of Education; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P.R. China
    • Dates

  • Journal of Chemical Sciences | News

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