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    • Keywords


      Indolylchalcones; indolylpyrazolines; microwave irradiation; stereoselectivity; antitumor; Hep-G2.

    • Abstract


      2-Aryl-$1H$-indole-3-carbaldehyde derivatives underwent Claisen-Schmidt condensation with acetophenone derivatives under microwave irradiation condition compared with the conventional heating to afford excellent yields of trans substituted indolylchalcones which subjected to condensation reaction with phenylhydrazine to afford their indolylpyrazoline analogs. The antitumor activity of the synthesized compounds was examined and evaluated against human hepatocellular carcinoma cell line (Hep-G2) as well as the half maximal inhibitory concentration (IC50). Most of them showed high potent antitumor activity.

    • Author Affiliations


      Magdy A H Zahran1 Hanan F Salama1 Yasmin G Abdin1 Amira M Gamal-Eldeen2

      1. Organic Chemistry Laboratory, Department of Chemistry, Faculty of Science, Menoufiya University, Shebin Elkom 32511, Menoufiya, Egypt
      2. Cancer Biology Laboratory, Center of Excellency for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt
    • Dates

  • Journal of Chemical Sciences | News

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