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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/122/04/0561-0569

    • Keywords

       

      Chiral 1,2-cyclohexyl diamines; macrocyclic amines; chiral solvating agents; enantiomeric purity; chiral carboxylic acids.

    • Abstract

       

      Efficient use of the readily accessible chiral $C_2$-symmetric acyclic diamines (1-2) as well as macrocyclic amines (3-5) containing trans-1,2-diaminocyclohexyl moiety as chiral solvating agents (CSA) for the determination of enantiomeric excess of representative carboxylic acids (6-7) and an amino acid derivative (8) is illustrated. The enantiomeric composition of different carboxylic acids estimated here by the 1H NMR method, based on the integration of the corresponding methine proton signals are in good correlation with that determined using HPLC method. The data are in accordance with the formation of multimolecular diastereomeric complexes in solution, which render good splitting of NMR signals for the enantiomers of representative carboxylic acids as well as for 𝑁-Ts-phenylglycine (up to $\Delta \Delta \delta = 0.295$ ppm, 118 Hz).

    • Author Affiliations

       

      Mariappan Periasamy1 Manasi Dalai1 Meduri Padmaja1

      1. School of Chemistry, University of Hyderabad, Central University P.O., Hyderabad 500 046
    • Dates

       
  • Journal of Chemical Sciences | News

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