• Synthesis and antiulcer activity of 2-[5-substituted-1-𝐻-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3𝐻) ones

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    • Keywords


      Synthesis; 4-quinazolinone; benzimidazole; antiulcer activity.

    • Abstract


      2-[5-substituted-1-𝐻-benzo(d)imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3𝐻)-one derivatives were synthesized and tested for antiulcer activity against pylorus ligation-induced, aspirin induced and ethanol induced ulcer in rat model. All the synthesized compounds were characterized by using IR, MS and 1H NMR spectral and elemental analysis. The compounds were scramed for their antiulcer activity: compounds 5k and 5n showed higher activity than omeprazole used as standard.

    • Author Affiliations


      Avinash Patil1 Swastika Ganguly2 Sanjay Surana3

      1. Smt. S.S. Patil College of Pharmacy, Chopda 425 107
      2. Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215
      3. R.C. Patel College of Pharmacy, Shirpur 425 405
    • Dates

  • Journal of Chemical Sciences | News

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