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    • Synthesis and antiulcer activity of 2-[5-substituted-1-𝐻-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3𝐻) ones

      Avinash Patil Swastika Ganguly Sanjay Surana

      Full Papers Volume 122 Issue 3 May 2010 pp 443-450

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/122/03/0443-0450

    • Keywords

       

      Synthesis; 4-quinazolinone; benzimidazole; antiulcer activity.

    • Abstract

       

      2-[5-substituted-1-𝐻-benzo(d)imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3𝐻)-one derivatives were synthesized and tested for antiulcer activity against pylorus ligation-induced, aspirin induced and ethanol induced ulcer in rat model. All the synthesized compounds were characterized by using IR, MS and 1H NMR spectral and elemental analysis. The compounds were scramed for their antiulcer activity: compounds 5k and 5n showed higher activity than omeprazole used as standard.

    • Author Affiliations

       

      Avinash Patil1 Swastika Ganguly2 Sanjay Surana3

      1. Smt. S.S. Patil College of Pharmacy, Chopda 425 107
      2. Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835 215
      3. R.C. Patel College of Pharmacy, Shirpur 425 405

    • Dates

       
      Published
      May 2010
      Manuscript received
      3 July 2009
      Accepted
      7 September 2009

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