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    • Keywords


      Biomedical polyurethane; controlled release; 5-flurouracil; drug delivery.

    • Abstract


      Novel biodegradable aliphatic poly(ether-urethane)s (PEUs) based on pluronic F-68 (PLF68) and castor oil were synthesized by the solution polymerization technique. These polymers were characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic spectroscopy (1HNMR) and gel permeation chromatography (GPC) to confirm the PEU formation and the molecular weight. Moderate molecular weight PEUs were obtained and converted into microspheres by solvent evaporation method to study the controlled release (CR) characteristics for 5-flurouracil (5-FU). PLF-68 acts as amphiphilic filler, which enhances the release of a hydrophobic drug such as 5-FU. Sizes of the microspheres as measured by laser light scattering technique ranged between 15 and 42 𝜇m. An increase in the size of particles was observed with increasing molar ratio of PLF-68 with respect to castor oil. The percentage encapsulation efficiency varied between 71 and 98. Surface morphology of the microspheres as studied by scanning electron microscopy (SEM) revealed the spherical nature of the particles with wrinkles on their surfaces. The release of 5-FU through the microspheres was investigated in pH 7.4-phosphate buffer. An increase in release rate was observed with increasing molar ratio of PLF68 with respect to castor oil.

    • Author Affiliations


      Reddy Seetharamareddy Harisha1 Kallappa Mahadevappa Hosamani1 Rangappa Sangappa Keri1 Namdev Shelke2 Vijay Kumar Wadi2 Tejaraj M Aminabhavi2

      1. P.G. Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003
      2. Drug Delivery Division, Center of Excellence in Polymer Science, Karnatak University, Pavate Nagar, Dharwad 580 003
    • Dates

  • Journal of Chemical Sciences | News

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