• Emerging trends at the interface of chemistry and biology: Applications to the design of human therapeutics

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    • Keywords


      Multi-target therapeutics; network biology; gene delivery; protein therapeutics; protein design.

    • Abstract


      This article describes recent developments in the design and implementation of various strategies towards the development of novel therapeutics using first principles from biology and chemistry. Strategies for multi-target therapeutics and network analysis with a focus on cancer and HIV are discussed. Methods for gene and siRNA delivery are presented along with challenges and opportunities for siRNA therapeutics. Advances in protein design methodology and screening are described, with a focus on their application to the design of antibody based therapeutics. Future advances in this area relevant to vaccine design are also mentioned.

    • Author Affiliations


      Santanu Bhattacharya1 Raghavan Varadarajan2

      1. Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012
      2. Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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