One pot, three component synthesis of 2-amino-4-aryl-3,5-dicyano-6-sulfanylpyridines and the corresponding 1,4-dihydropyridines are from readily accessible starting materials is described. Simply heating of an ethanolic solution of structurally diverse aldehydes with various thiols and malononitrile in the presence of nanocrystalline magnesium oxide provides the highly substituted pyridine derivatives in moderate to high yields, each representing a privileged medicinal scaffold with their structural motif. After completion of the reaction, the catalyst can be recovered efficiently and reused with constintent activity.
Volume 132, 2020
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode