• Voltammetric sensor for D-penicillamine determination based on its electrocatalytic oxidation at the surface of ferrocenes modified carbon paste electrodes

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    • Keywords


      D-Penicillamine; ferrocenes; carbon paste electrode; electrocatalytic.

    • Abstract


      Electrocatalytic oxidation of D-penicillamine (D-PA) at the surface of ferrocene modified carbon paste electrode (FCCPE) was thoroughly investigated in aqueous solution with various pH. The performance of this modified electrode was compared with those of 2,7-bis(ferrocenyl ethyl) fluoren-9-one modified carbon paste electrode (2,7-BFEFMCPE). In the optimum condition, the oxidation of D-PA at the surface of FCCPE and 2,7-BFEFMCPE is occurred about 480 and 320 mV less positive than that unmodified carbon paste electrode, respectively. The linear dynamic ranges $6 \times 10^{-5}$ M$^{-2} \times 10^{-3}$ M, $6.5 \times 10^{-5}$ M-$1.1 \times 10^{-3}$ M and $7\times 10^{-6}$ M-$1.6 \times 10^{-4}$M, $7 \times 10^{-6}$ M-$2 \times 10^{-4}$ M of D-PA are obtained from CV and DPV methods for FCCPE and 2,7-BFEFMCPE, respectively. The detection limits (3𝜎) were determined as $5.4 \times 10^{-5}$ M and $6.3 \times 10^{-5}$ M in CV and $6.2 \times 10^{-6}$ M and $6.8 \times 10^{-6}$ M in DPV determinations for FCCPE and 2,7-BFEFMCPE, respectively. The proposed method was applied in a highly sensitive determination of D-PA in drug and human synthetic serum samples by standard addition and recovery methods, respectively.

    • Author Affiliations


      Jahan-Bakhsh Raoof1 Reza Ojani1 Fereshteh Chekin1

      1. Electroanalytical Chemistry Research Laboratory, Department of Chemistry, Faculty of Basic Science, Mazandaran University, Babolsar, Iran
    • Dates

  • Journal of Chemical Sciences | News

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