• Towards chiral diamines as chiral catalytic precursors for the borane-mediated enantioselective reduction of prochiral ketones

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      https://www.ias.ac.in/article/fulltext/jcsc/121/06/1003-1010

    • Keywords

       

      ($3S$)-3-Anilinomethyl-1,2,3,4-tetrahydroisoquinoline; ($2R$)-2-anilinomethylpiperidine; (𝑆)-phenylalanine; asymmetric reduction.

    • Abstract

       

      Two chiral diamines ($3S$)-3-anilinomethyl-1,2,3,4-tetrahydroisoquinoline (1) and ($2R$)-2-anilinomethylpiperidine (2) have been employed as chiral catalytic sources in the borane-mediated asymmetric reduction of prochiral ketones thus providing the resulting secondary alcohols in good enantiomeric purities (up to 81% $ee$).

    • Author Affiliations

       

      Deevi Basavaiah1 Utpal Das1 Suparna Roy1

      1. School of Chemistry, University of Hyderabad, Hyderabad 500 046
    • Dates

       
  • Journal of Chemical Sciences | News

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