• Synthesis, antimicrobial and antifungal activities of novel 1H-1,4-diazepines containing pyrazolopyrimidinone moiety

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    • Keywords


      1,4-Diazepines; 𝛽-diketones/𝛽-ketoesters; 𝑝-toluenesulfonic acid; pyrazolo pyrimidinones.

    • Abstract


      Acylation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-$7H$-pyrazolo [4,3-d) pyrimidin-7-one 1 with chloroacetylchloride in the presence of anyhydrous aluminium chloride affords 5-[(5-chloroacetyl-2-ethoxy)phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3-d] pyrimidin-7-one 2. The compound 2 condensed with various 𝛽-diketones/𝛽-ketoesters compound, to obtain new 𝛽-diketones/𝛽-ketoesters 4a-i treated with ethylenediamine (EDA) gives 1H-1,4-diazepines. The compounds 5a-i has been screened for antimicrobial, antifungal and anthelmintic activities.

    • Author Affiliations


      Rajesh Kumar1 Yogesh Chandra Joshi1

      1. Department of Chemistry, University of Rajasthan, Jaipur 302 004
    • Dates

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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