Acylation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-$7H$-pyrazolo [4,3-d) pyrimidin-7-one 1 with chloroacetylchloride in the presence of anyhydrous aluminium chloride affords 5-[(5-chloroacetyl-2-ethoxy)phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo [4,3-d] pyrimidin-7-one 2. The compound 2 condensed with various 𝛽-diketones/𝛽-ketoesters compound, to obtain new 𝛽-diketones/𝛽-ketoesters 4a-i treated with ethylenediamine (EDA) gives 1H-1,4-diazepines. The compounds 5a-i has been screened for antimicrobial, antifungal and anthelmintic activities.
Volume 133, 2021
Continuous Article Publishing mode
Click here for Editorial Note on CAP Mode