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      https://www.ias.ac.in/article/fulltext/jcsc/121/04/0471-0479

    • Keywords

       

      Trichostatic acid; HDAC; inhibitor.

    • Abstract

       

      New substituted trichostatic acid derivatives have been synthesized and evaluated for their biological activities towards the H661 non-small lung cancer cell line. These syntheses were achieved by alkylation of propiophenones to introduce the side chain with a terminal precursor of hydroxamic acid and aminobenzamide derivatives. The first fluorinated derivatives of trichostatic acid are described, such as 6-fluoro trichostatin A, with antiproliferative activities in the micromolar range and with histone deacetylase inhibitory activity.

    • Author Affiliations

       

      Cédric Charrier1 Joëlle Roche2 Jean-Pierre Gesson1 Philippe Bertrand1

      1. Synthèse et Réactivité des Substances Naturelles, CNRS UMR 6514, Université de Poitiers: 40 Avenue du Recteur Pineau, Poitiers, F-86022, France
      2. Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Université de Poitiers: 40 Avenue du Recteur Pineau, Poitiers, F-86022, France
    • Dates

       
  • Journal of Chemical Sciences | News

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