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https://www.ias.ac.in/article/fulltext/jcsc/121/04/0463-0470

Lamotrigine; ammonium; crystal structure; antibacterial activity.

Antiepileptic drug lamotrigine and its thirteen ammonium salt complexes (4a-4m) were synthesized and characterized by IR, elemental analysis, ¹H-NMR, and MS spectral methods. Many of the ammonium salts (4a-4m) were first reported. Furthermore, the crystal structure of compound 3 was determined by single crystal X-ray diffraction analysis. All these complexes were tested in vitro for their antibacterial activity (Bacillus subtilis, Staphylococcus aureus, Enterococus faecalis, Escherichia coli, Pseudomonas aeruginosa and Enterobacter cloacae). The results indicated that most of the complexes showed good antibacterial activity against Gram-positive (B. subtilis, S. aureus and S. faecalis), but showed mild, even inactive against Gram-negative bacterial strains.

Yong Qian¹ Peng-Cheng Lv¹ Lei Shi¹ Rui-Qin Fang¹ Zhong-Cheng Song¹ Hai-Liang Zhu¹

1. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People’s Republic of China

Published

July 2009

Manuscript received

2 December 2008

Manuscript revised

6 March 2009

Accepted

1 April 2009