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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/121/04/0463-0470

    • Keywords

       

      Lamotrigine; ammonium; crystal structure; antibacterial activity.

    • Abstract

       

      Antiepileptic drug lamotrigine and its thirteen ammonium salt complexes (4a-4m) were synthesized and characterized by IR, elemental analysis, 1H-NMR, and MS spectral methods. Many of the ammonium salts (4a-4m) were first reported. Furthermore, the crystal structure of compound 3 was determined by single crystal X-ray diffraction analysis. All these complexes were tested in vitro for their antibacterial activity (Bacillus subtilis, Staphylococcus aureus, Enterococus faecalis, Escherichia coli, Pseudomonas aeruginosa and Enterobacter cloacae). The results indicated that most of the complexes showed good antibacterial activity against Gram-positive (B. subtilis, S. aureus and S. faecalis), but showed mild, even inactive against Gram-negative bacterial strains.

    • Author Affiliations

       

      Yong Qian1 Peng-Cheng Lv1 Lei Shi1 Rui-Qin Fang1 Zhong-Cheng Song1 Hai-Liang Zhu1

      1. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People’s Republic of China

    • Dates

       
      Published
      July 2009
      Manuscript received
      2 December 2008
      Manuscript revised
      6 March 2009
      Accepted
      1 April 2009

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