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    • Synthesis and cellular cytotoxicities of new 𝑁-substituted indole-3-carbaldehyde and their indolylchalcones

      Magdy A H Zahran Atef M Ibrahim

      Volume 121 Issue 4 July 2009 pp 455-462

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/121/04/0455-0462

    • Keywords

       

      𝑁-alkylation; indolylchalcones; antitumor; microwave irradiation.

    • Abstract

       

      A simple and efficient method for 𝑁-alkylation of indole-3-carbaldehyde derivatives using a mixture of different bases in DMF under conventional and microwave irradiation conditions to afford 𝑁-substituted indole-3-carbaldehyde derivatives 3a-o is reported. These derivatives which undergo Claisen-Schmidt condensation with 1-biphenyl-4-yl-ethanone yielded the corresponding indolylchalcone derivatives 5a-h. A comparative study showed that the microwave irradiation condition afforded excellent yield and shorten reaction time of all the synthesized indole derivatives which possess promising antitumor activity as well as interchelation bioactivity of indolylchalcones 5a-h with DNA.

    • Author Affiliations

       

      Magdy A H Zahran1 Atef M Ibrahim2

      1. Organic Chemistry Laboratory, Department of Chemistry, Faculty of Science, Menoufiya University, 32511, Egypt
      2. Department of Microbiology and Biotechnology, Genetic Engineering and Biotechnology Institute, Menoufiya University, 32511, Egypt

    • Dates

       
      Published
      July 2009
      Manuscript received
      21 November 2008
      Manuscript revised
      6 February 2009
      Accepted
      10 February 2009

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