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    • Keywords


      Thienopyrimidine; triazolothienopyrimidine; Gewald reaction; antibacterial activity; antifungal activity.

    • Abstract


      Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.

    • Author Affiliations


      Nitinkumar S Shetty1 Ravi S Lamani1 Imtiyaz Ahmed M Khazi1

      1. Department of Chemistry, Karnatak University, Dharwad 580 003
    • Dates

  • Journal of Chemical Sciences | News

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