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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/121/03/0301-0307

    • Keywords

       

      Thienopyrimidine; triazolothienopyrimidine; Gewald reaction; antibacterial activity; antifungal activity.

    • Abstract

       

      Novel tricyclic thienopyrimidines (3, 5, 6, 9, 11, 12) and triazole fused tetracyclic thienopyrimidines (4a-c, 10a-c) were synthesized from precursors 2-amino-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 and 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothio-phene-3-carbonitrile 7 respectively. The corresponding precursors were prepared by employing the Gewald reaction. The structures of newly synthesized compounds were characterized by spectral and analytical data. All the compounds were screened for their biological activities. Some of the compounds displayed promising antibacterial and antifungal activities.

    • Author Affiliations

       

      Nitinkumar S Shetty1 Ravi S Lamani1 Imtiyaz Ahmed M Khazi1

      1. Department of Chemistry, Karnatak University, Dharwad 580 003

    • Dates

       
      Published
      May 2009
      Manuscript received
      1 July 2008
      Manuscript revised
      3 September 2008

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