A novel, practical and environmentally benign approach has been developed for the oxidation of methylarenes using H2O2-HBr system in water. Arylaldehydes containing electon-withdrawing groups are isolated in good to high yields. Methylarenes containing electon-donating groups, in contrast, are transformed into bromo-substituted arylaldehyde undergoing a tandem oxidation-bromination process.
Volume 133, 2021
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