• Influence of alkali and alkaline earth ions on the 𝑂-alkylation of the lower rim phenolic-OH groups of 𝑝-tert-butyl-calix[4]arene to result in amide-pendants: Template action of K+ and the structure of K+ bound tetra-amide derivative crystallized with a 𝑝-tert-butylcalix[4]arene anion

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    • Keywords

       

      𝑂-alkylation at the lower rim of calix[4]arene; template action of K+; mono-anion of 𝑝-tert-butyl-calix[4]arene; alkali and alkaline earth ions.

    • Abstract

       

      Role of alkali and alkaline earth ions on the formation of calix[4]arene-amide derivatives through 𝑂-alkylation of the lower rim phenolic-OH groups in general and template action of K+ in particular have been explored. Na+ and K+ ions among alkali, and Ca2+ and Sr2+ ions among alkaline earth have shown tetra-amide derivatives bound to metal ion species. Among all these, potassium salts act as template and yields a K+ bound tetra-amide derivative where the charge is counter balanced by a calix[4] arene-monoanion and the product is crystallographically characterized. Change in the amide precursor used in these 𝑂-alkylation reactions has no effect on the type of the amide derivative formed. Also demonstrated is a direct one-step reaction for the preparation of 1,3-di-amide derivative in high yield and low reaction period using CsHCO3.

    • Author Affiliations

       

      Amjad Ali1 2 Chebrolu P Rao1 Philippe Guionneau3

      1. Bioinorganic Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076
      2. School of Chemistry and Biochemistry, Thapar University, Patiala 147 004
      3. Institut de Chimie de la Matiere Condensee de Bordeaux, UPR 9048 CNRS, Pessac, France
    • Dates

       
  • Journal of Chemical Sciences | News

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