• Efficient resolution of (±)-rans-2,3-diphenylpiperazine using ($1S$)-(+)-10-camphorsulfonic acid and enrichment of enantiomeric purity of non-racemic 2,3-diphenylpiperazine using different achiral acids

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    • Keywords


      2,3-Diphenylpiperazine; camphorsulfonic acid; resolution; homochiral aggregates; heterochiral aggregates.

    • Abstract


      Enantiomerically pure (𝑅,𝑅)-(+)-2,3-diphenylpiperazine with 98% $ee$ was obtained by resolution of the corresponding racemic mixture using ($1S$)-(+)-10-camphorsulfonic acid. The partially resolved enriched sample of (𝑆,𝑆)-(-)-2,3-diphenylpiperazine with 73% ee was purified to obtain samples of 97% ee using different achiral acids via the preparation of either homochiral or heterochiral hydrogen bonded aggregates.

    • Author Affiliations


      Pothiappan Vairaprakash1 Mariappan Periasamy1

      1. School of Chemistry, University of Hyderabad, Hyderabad 500 046
    • Dates

  • Journal of Chemical Sciences | News

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