• Dioxygen reactivity ofmeso-hydroxylated hemes: Intermediates in heme degradation process catalyzed by heme oxygenase

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      https://www.ias.ac.in/article/fulltext/jcsc/118/06/0463-0474

    • Keywords

       

      Heme oxygenase; heme degradation; coupled oxidation; variable temperature paramagnetic NMR

    • Abstract

       

      Heme oxygenase (HO) is the only enzyme in mammals known to catalyse the physiological degradation of unwanted heme into biliverdin, Fe ion and CO. The process involves introduction of the hydroxyl group at one of itsmeso-positions as the first fundamental step of the heme cleavage process. It was also found thatmeso-amino heme undergoes similar ring-cleavage process while reacting with dioxygen in presence of pyridine as an axial ligand. The present paper briefly reviews the reactions of modelmeso-hydroxylated heme and its analogues with dioxygen, and their relevance in the heme degradation process.

    • Author Affiliations

       

      Sankar Prasad Rath1

      1. Department of Chemistry, Indian Institute of Technology, Kanpur - 208 016
    • Dates

       
  • Journal of Chemical Sciences | News

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