• Sodium borohydride reduction of aromatic carboxylic acids via methyl esters

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    • Keywords


      Reduction; sodium borohydride; aromatic methyl esters

    • Abstract


      A number of important aromatic carboxylic acids precursors, or intermediates in the syntheses of natural products, are converted into methyl esters and reduced to the corresponding primary alcohols using a sodium borohydride-THF-methanol system. The alcohols are obtained in 70–92% yields in 2–5 hours, in a pure state. This two-step procedure not only provides a better alternative to aluminum hydride reduction of acids but also allows the selective reduction of esters in presence of acids, amides, nitriles or nitro functions which are not affected under these conditions.

    • Author Affiliations


      Aamer Saeed1 Zaman Ashraf1

      1. Department of Chemistry, Quaid-I-Azam University, Islamabad - 45320, Pakistan
    • Dates

  • Journal of Chemical Sciences | News

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