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    • Sodium borohydride reduction of aromatic carboxylic acids via methyl esters

      Aamer Saeed Zaman Ashraf

      Volume 118 Issue 5 September 2006 pp 419-423

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/118/05/0419-0423

    • Keywords

       

      Reduction; sodium borohydride; aromatic methyl esters

    • Abstract

       

      A number of important aromatic carboxylic acids precursors, or intermediates in the syntheses of natural products, are converted into methyl esters and reduced to the corresponding primary alcohols using a sodium borohydride-THF-methanol system. The alcohols are obtained in 70–92% yields in 2–5 hours, in a pure state. This two-step procedure not only provides a better alternative to aluminum hydride reduction of acids but also allows the selective reduction of esters in presence of acids, amides, nitriles or nitro functions which are not affected under these conditions.

    • Author Affiliations

       

      Aamer Saeed1 Zaman Ashraf1

      1. Department of Chemistry, Quaid-I-Azam University, Islamabad - 45320, Pakistan

    • Dates

       
      Published
      September 2006
      Manuscript received
      7 July 2005
      Manuscript revised
      25 January 2006

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