• Thiol peroxidase-like activity of some intramolecularly coordinated diorganyl diselenides

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    • Keywords

       

      Selenium; diorganodiselenide; ferrocenamide; thiol peroxidase; antioxidant

    • Abstract

       

      Several new diaryl diselenides having intramolecular coordinating groups have been synthesized by ortho-lithiation/Na2Se2 routes in good yield. Bis[2-(N-phenylferrocenecarboxamide)] diselenide (10), bis[2-(N-tert-butylferrocenecarboxamide)] diselenide (11), (S)(S)-bis[2(-N-phenethylferrocene-carboxamide)] diselenide (12) were synthesized by the ortho-lithiation route. Bis[2-(N,N-dimethyl-aminomethylnaphthyl)] diselenide (13) was synthesized by lithium/bromide exchange reaction whereas bis(2,4-dinitrophenyl) diselenide (14) was prepared by the reaction of disodium diselenide with 2,4-dinitro-1-chlorobenzene. Thiol peroxidase-like activities of the diorganodiselenides have been evaluated by using H2O2 as substrate and PhSH as cosubstrate. Diselenides (13) and (14) with dimethylami-nomethyl- or nitro-donor groups in close proximity to selenium, show much better thiol peroxidase-like activities compared to diselenides10–12 with amide donor groups. Cyclic voltammetry study of diselenides10–12 derived from redox-active ferrocenamide has been carried out.

    • Author Affiliations

       

      Sangit Kumar1 Harkesh B Singh1

      1. Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai - 400 076, India
    • Dates

       
  • Journal of Chemical Sciences | News

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