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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/117/02/0175-0178

    • Keywords

       

      Cyclophosphazene hydrazides; metalated cyclophosphazenes; zinc complexes; phosphate ester hydrolysis; DNA cleavage

    • Abstract

       

      Catalytic activity of [L2.Zn][NO3]2] (L = spiro-N3P3[O2C12H8][N(CH3)NH2]) towards the hydrolysis of two phosphodiesters, [bis(p-nitrophenyl)phosphate, bNPP] and [2-(hydroxypropyl)-p-nitrophenyl phosphate, hNPP] has been examined. While the rate of hydrolysis of the former is accelerated over a million-fold, the rate of hydrolysis of the latter also is enhanced considerably. Detailed kinetic evaluation of these reactions has been carried out and all the kinetic parameters including the Michaelis-Menten parameters are reported. The catalyst [L2.Zn][NO3]2] has also been found to be an effective nuclease. Relaxation of supercoiled plasmid DNA, pBR322, occurs in presence of [L2.Zn][NO3]2 without the need for any exogenous reagents.

    • Author Affiliations

       

      Vadapalli Chandrasekhar1 Venkatasubbiah Krishnan1 Ramachandran Azhakar1 C Madhavaiah1 Sandeep Verma1

      1. Department of Chemistry, Indian Institute of Technology, Kanpur - 208 016, India

    • Dates

       
      Published
      March 2005
      Final version published online
      14 March 2016

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