• Mixed-ligand complexes of ruthenium(II) incorporating a diazo ligand: Synthesis, characterization and DNA binding

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      https://www.ias.ac.in/article/fulltext/jcsc/117/02/0153-0159

    • Keywords

       

      Ruthenium(II) polypyridyl complexes; 9-diazo-4,5-diazafluorene ligand; DNA binding

    • Abstract

       

      Mixed-ligand complexes of the type [Ru(N-N)2(dzdf)]Cl2, where N-N is 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen) and 9-diazo-4,5-diazafluorene (dzdf), have been synthesized and characterized by elemental analysis, UV-Vis, IR and NMR spectroscopy. Binding of these complexes with calf thymus DNA (CT-DNA) has been investigated by absorption spectroscopy, steady-state emission spectroscopy and viscosity measurements. The experimental results indicate that the size and shape of the intercalating ligands have marked effect on the binding affinity of the complexes to CT-DNA. The complex [Ru(phen)2(dzdf)]Cl2 binds with CT-DNA through an intercalative binding mode, while the complex [Ru(bpy)2(dzdf)]Cl2 binds electrostatically.

    • Author Affiliations

       

      Megha S Deshpande1 Avinash S Kumbhar1

      1. Department of Chemistry, University of Pune, Pune - 411 007, India
    • Dates

       
  • Journal of Chemical Sciences | News

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