• Studies on NaI/DMSO inducedretro-Michael addition (RMA) reactions on some 1,5-dicarbonyl compounds

    • Fulltext


        Click here to view fulltext PDF

      Permanent link:

    • Keywords


      retro-Michael addition; microwave-mediated organic reactions; retro reactions

    • Abstract


      Studies on the reaction of some 1,5-ketodiesters/1,5-diketones with NaX (X = Cl/Br/I)/DMSO have shown that under microwave/thermal conditions, facileretro-Michael addition (RMA) reaction takes place instead of formation of the expected Krapcho products. Mechanistic studies have shown that the NaI/DMSO system is a better system than NaCl/DMSO or NaBr/DMSO to promote the RMA pathway and DMSO is an essential requirement. The electrophilic halide ion could be involved in this fragmentation reaction.

    • Author Affiliations


      H Surya Prakash Rao1 S Jothilingam1

      1. Department of Chemistry, Pondicherry University, Pondicherry - 605 014, India
    • Dates

  • Journal of Chemical Sciences | News

© 2021-2022 Indian Academy of Sciences, Bengaluru.