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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/116/05/0265-0270

    • Keywords

       

      Spirobenzodiazepines; distereotopic protons; antianxiety activity

    • Abstract

       

      3-Acetyl coumarins (1) when allowed react with isatin (2) gave corresponding 3-(3′-hydroxy-2′-oxo indolo) acetyl coumarins (3), which on dehydration afforded the correspondingα,β-unsaturated ketones (4). Cyclocondensation of (4) with substitutedo-phenylene diamines resulted in novel 3-coumarinyl spiro[indolo-1,5-benzodiazepines] (5). Structures of all the compounds have been established on the basis of their IR, NMR and mass spectral data and have been screened for their antimicrobial activity and antianxiety activity in mice

    • Author Affiliations

       

      Raviraj A Kusanur1 Manjunath Ghate2 Manohar V Kulkarni1

      1. Department of Studies in Chemistry, Karnataka University, Dharwad - 580 003, India
      2. Kripanidhi College of Pharmacy, Bangalore, India

    • Dates

       
      Published
      September 2004
      Manuscript received
      17 May 2004
      Manuscript revised
      4 August 2004

  • Journal of Chemical Sciences | News

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      Posted on July 25, 2019

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