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Spirobenzodiazepines; distereotopic protons; antianxiety activity

3-Acetyl coumarins (1) when allowed react with isatin (2) gave corresponding 3-(3′-hydroxy-2′-oxo indolo) acetyl coumarins (3), which on dehydration afforded the correspondingα,β-unsaturated ketones (4). Cyclocondensation of (4) with substitutedo-phenylene diamines resulted in novel 3-coumarinyl spiro[indolo-1,5-benzodiazepines] (5). Structures of all the compounds have been established on the basis of their IR, NMR and mass spectral data and have been screened for their antimicrobial activity and antianxiety activity in mice

Raviraj A Kusanur¹ Manjunath Ghate² Manohar V Kulkarni¹

1. Department of Studies in Chemistry, Karnataka University, Dharwad - 580 003, India
2. Kripanidhi College of Pharmacy, Bangalore, India

Published

September 2004

Manuscript received

17 May 2004

Manuscript revised

4 August 2004