• Microwave-mediated reductive amination-cyclization of 4-aryl-4-oxobutanoates: Facile synthesis of 3-methylidene-5-phenyl-2,3-dihydropyrrolidones

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/116/03/0163-0168

    • Keywords

       

      Microwaves; three-component coupling; pyrrolidones; ammonium formate

    • Abstract

       

      Microwave-mediated three-component condensation of 4-aryl-4-oxobutanoates with ammonium formate furnishes 3-methylidene-5-phenyl-2,3-dihydropyrrolidones in good yield within 2 min. The pyrrolidone products were characterized on the basis of spectral data and X-ray crystal structure analysis. The reaction is found to be general and a variation in the ester and aryl moieties is possible. However, when alkylammonium formate is used only amide products are formed

    • Author Affiliations

       

      H Surya Prakash Rao1 S P Senthilkumar1

      1. Department of Chemistry, Pondicherry University, Pondicherry - 605 014, India
    • Dates

       
  • Journal of Chemical Sciences | News

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