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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/115/05-06/0373-0400

    • Keywords

       

      Peptide design; crystal structures; C-H…O hydrogen bond; hybrid peptides; D-amino acids; β-amino acids

    • Abstract

       

      An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the useα-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments andDPro-Xxx segments for nucleating ofβ-hairpin structures.β- andγ-amino acid residues have been used to expand the range of designed polypeptide structures.

    • Author Affiliations

       

      S Aravinda1 N Shamala1 Rituparna S Roy2 P Balaram2 3

      1. Department of Physics, Indian Institute of Science, Bangalore - 560 012, India
      2. Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560 012, India
      3. Chemical Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur Campus, Jakkur PO, Bangalore - 560 064, India

    • Dates

       
      Published
      12 October 2003

  • Journal of Chemical Sciences | News

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