• Altered redox affinity of xanthine oxidase active sites by copper(II) ions

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    • Keywords


      Xanthine oxidase; redox reaction; Cu2+-XO interaction

    • Abstract


      The interaction of Cu2+ ion with the redox centres of xanthine oxidase (XO) has been investigated using optical difference spectroscopic measurements. Anaerobic enzyme-reduction experiments using controlled and excess substrates (xanthine and NADH) have been performed to investigate the perturbation of XO active sites in the presence of Cu2+ ions. The results indicate an overall alteration in the redox affinities (i.e. affinity to accept electrons) of the active sites of XO by Cu2+ ion.

    • Author Affiliations


      Madhu Sudan Mondal1 Samaresh Mitra1

      1. Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai - 400 005, India
    • Dates

  • Journal of Chemical Sciences | News

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