• Matrix metalloproteinases: Regulation and biological functions

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    • Keywords


      Collagenase; gelatinase; stromelysin; MT-MMP

    • Abstract


      Remodeling of the extracellular matrix occurs during many physiological and pathological conditions. The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases that are responsible for the proteolytic degradation of number of extracellular matrix (ECM) components. Regulation of MMP activity both at transcriptional and translational levels modulates the degradation of ECM components. Although most MMPs have similar regulatory mechanisms, certain MMPs have unique mechanims of activation at the cell surface. Understanding the processes that regulate the expression of MMPs is important since an imbalance between MMPs and their natural inhibitors, tissue inhibitors of metalloproteinses, leads to a pathological situation such as cancer. In this review, we will briefly discuss various MMPs, their structure, regulation and function.

    • Author Affiliations


      Shravan K Chintala1 Jasti S Rao1

      1. Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX - 77030, USA
    • Dates

  • Journal of Chemical Sciences | News

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