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    • Keywords


      3′-Azido-3′-deoxy-β-thymidine; β-thymidine; D-xylose; anti-AIDS agents

    • Abstract


      β-thymidine is a key intermediate in the manufacturing of anti-AIDS agents- AZT and d4 T. A practical and economically viable route to β-thymidine starting from inexpensive D-xylose has been described. This synthetic route is based on a new rearrangement leading to 2,2′-anhydro-formation with concomitant epimerisation at C-3′, observed for the first time in nucleoside chemistry.

    • Author Affiliations


      A V Rama Rao1 M K Gurjar1 S V S Lalitha1 Sasmita Tripathy1

      1. Indian Institute of Chemical Technology, Hyderabad - 500 007, India
    • Dates

  • Journal of Chemical Sciences | News

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