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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/106/06/1329-1340

    • Keywords

       

      Biradicals; EPR spectroscopy; simulation; thermodynamic parameters; conformational changes; fast and slow exchanges

    • Abstract

       

      Four biradicals of differing chain lengths have been prepared by spin-labelling the sulphhydryl groups of dithiothreitol. Temperature-dependent EPR spectra of these biradicals indicate that the dynamics of biradicals is associated with both fast and slow exchanges of conformations. The three-conformational model incorporating cage configuration is found to be more appropriate. Certain thermodynamic parameters of conformationalchanges have been calculated from the experimental EPR parameters, obtained by the use of simulation procedures developed recently.

    • Author Affiliations

       

      S Sankarapandi1 J M Rifkind2 P T Manoharan1

      1. Department of Chemistry, Indian Institute of Technology, Madras - 600 036, India
      2. Laboratory of Cellular and Molecular Biology, Gerontology Research Center, NIA/NIH, Baltimore, Maryland - 21224, USA
    • Dates

       
  • Journal of Chemical Sciences | News

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