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    • Keywords


      Diffusional release of solutes; release kinetics; polymer matrices

    • Abstract


      Diffusional release of solutes from polymer matrices undergoing structural changes has been analysed by incorporating the dependence of solute diffusivity on time. The functional dependence of diffusivity with time has been experimentally verified and its utility and limitations are discussed. Criteria for predicting release characteristics have been arrived at based on two model parameters,K and β. HereK represents the reciprocal of the time required for the structural change and β is the ratio of the solute diffusivity prior to the onset and after the completion of the structural change. The criteria, which are independent of the mechanistic details of the structural change, have been validated by analysing solute release from polymeric matrices undergoing diverse structural changes. The approach should be useful in predicting the relase characteristics of solutes on the basis of the physicochemical characteristics of the polymer-solute systems. It should also help in tailoring the polymers to obtain the desired release kinetics.

    • Author Affiliations


      V Premnath1 V S Vadalkar1 M G Kulkarni1 R A Mashelkar1 2

      1. Chemical Engineering Division, National Chemical Laboratory, Pune - 411 008, India
      2. Jawaharlal Nehru Centre for Advanced Scientific Research, Indian Institute of Science Campus, Bangalore - 560 012, India
    • Dates

  • Journal of Chemical Sciences | News

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