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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/106/05/1051-1070

    • Keywords

       

      Attenuation; uracil; non-covalent interactions; stacking profile

    • Abstract

       

      Uracils having enhanced stacking profile are of interest from diverse vantages ranging from the chemical simulation of transcription to the design of novel anti viral agents. This objective has been realized by synthetic strategies leading to uracils having,inter alia, pseudo aromatic and hydrophobic rings crafted to the 5–6 location and ionophore and hydrophobic chains affixed at the C-5 and nitrogen atoms. Endeavours to prepare a 5–2′ uracil-pyrimidine composite have led to novel uracil arising from 2–O → =CH(COOR)2 transformation and a tethered malonic acid pyrimidine complex.

    • Author Affiliations

       

      Subramania Ranganathan1 2 Dinabandhu Kundu1 Sanjiv Mehrotra1

      1. Department of Chemistry, Indian Institute of Technology, Kanpur - 208016, India
      2. Bio-molecular Research Unit, Regional Research Laboratory, Trivandrum - 695019, India
    • Dates

       
  • Journal of Chemical Sciences | News

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