• Chiral rhodium carboxylates as asymmetric hydrogenation catalysts

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    • Keywords


      Asymmetric; hydrogenation; rhodium; catalysts; carboxylates

    • Abstract


      The comparative catalytic activities of a few chiral rhodium carboxylato complexes in combination with chiral and achiral phosphines are described. In the hydrogenation of α-acetamidocinnamic acid and its methyl ester, differences are observed in turnover numbers and enantioselectivities. Diastereomeric interactions between chiral carboxylato and chiral phosphine moieties resulting in different rates are clearly seen. Arrhenius plots of (+) and (-) DIOP [DIOP = 2,3 isopropylidene 2,3 dihydroxy-1,4bis (diphenylphosphino) butane] with rhodium (-) mandalato complex give markedly different activation energies.

    • Author Affiliations


      Sumit Bhaduri1 Hanif Khwaja1

      1. Alchemie Research Centre, Thane-Belapur Road, P O Box 155, Thane 400 601, Maharashtra, India
    • Dates

  • Journal of Chemical Sciences | News

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