• Polymer-ligand interaction studies. Part I. Binding of some drugs to poly(N-vinyl-2-pyrrolidone)

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    • Keywords


      Poly(N-vinyl-2-pyrrolidone); drug-binding; fluorescence competition method; π-π interaction

    • Abstract


      A physico-chemical investigation on the binding of some nonsteroidal anti-inflammatory drugs, Naproxen (NP) and Ketoprofen (KP) and a drug model compound, salicylic acid (SA) to poly(N-vinyl-2-pyrrolidone) (PVP, molecular weight = 360,000), was performed at pH 7.1 by the fluorescence competition method employing 1-anilinonaphthalene-8-sulphonate (ANS) as the fluorescent probe. The binding affinities of these substrates to PVP are in the order KP < SA < NP which has been explained on the basis of their structural features and the consequent effect on the interacting forces. Theπ-π interaction between the carbonyl group of PVP and theπ-ring system of the substrate molecule seems to be crucial in deciding the binding affinities of the substrates

    • Author Affiliations


      Meenakshi Maruthamuthu1 E Subramanian1 2

      1. Department of Physical Chemistry, University of Madras, A C College Campus, Madras - 600 025, India
      2. Department of Chemistry, Manonmaniam Sundaranar University, St. Mark’s Road, Palayamkottai 627 002, Tamil Nadu, India
    • Dates

  • Journal of Chemical Sciences | News

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