• Synthesis and biological activity of 4-(N-arylidene acetylhydrazido)-1,4-benzothiazin-2,3-diones, azetidinones and thiazolidinones

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    • Keywords


      Synthesis; biological activity; benzothiazinones; azetidinones; thiazolidinones

    • Abstract


      1,4-Benzothiazin-2,3-dione (I) on N-methyl ethoxylation with ethyl chloracetate gives (II) which on reaction with hydrazine hydrate yields 4-(acetylhydrazido)-1,4-benzothiazin-2,3-dione (III). This was further condensed with different aldehydes to form the 4-(N-arylidene acetylhydrazido)-1,4-benzothiazin-2,3-dione (IV). These compounds are converted into a series of β-lactams (V) and 4-thiazolidinones (IV). The antibacterial and antifungal activities of the compounds have been determined.

    • Author Affiliations


      M Hogale1 A Uthale1

      1. Department of Chemistry, Shivaji University, Kolhapur - 416004, India
    • Dates

  • Journal of Chemical Sciences | News

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