• Theoretical conformational study of the molecular structures of some bipyridine cardiotonics

    • Fulltext


        Click here to view fulltext PDF

      Permanent link:

    • Keywords


      Bipyridine cardiotonics; conformational features; amrinone; milrinone

    • Abstract


      Conformational features of amrinone and milrinone have been examined viaab initio (at STO-3G and 3–21G levels) MO theory. The calculated results suggest twisted structures for both the molecules. The higher barrier to rotation of the pyridine ring and restricted conformational flexibility of milrinone are observed to be two significant factors responsible for its greater cardiotonic activity as compared to that of amrinone.

    • Author Affiliations


      Apurba Krishna Bhattacharjee1

      1. Department of Chemistry, Lady Keane College, Shillong - 793001, India
    • Dates

  • Journal of Chemical Sciences | News

© 2021-2022 Indian Academy of Sciences, Bengaluru.