• Some new aspects of benzyne and radical mediated cyclisations

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/100/02-03/0217-0222

    • Keywords

       

      Benzyne intermediates; radical intermediates; cyclisation; isoquinoline alkaloids.

    • Abstract

       

      KNH2/NH3 cyclisations of some alkoxy substituted arylhalides proceed in poor yields. This shortcoming may be overcome by the use of LDA/THF to effect the ring closure which may occur through benzyne or radical intermediates. Besides ortho halogenated dihydroanils and amides, the cyclisation of the benzylamine Schiff bases also provides a convenient route to isoquinoline alkaloids.

    • Author Affiliations

       

      S V Kessar1

      1. Department of Chemistry, Panjab University, Chandigarh - 160014, India
    • Dates

       
  • Journal of Chemical Sciences | News

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