Some new aspects of benzyne and radical mediated cyclisations
KNH2/NH3 cyclisations of some alkoxy substituted arylhalides proceed in poor yields. This shortcoming may be overcome by the use of LDA/THF to effect the ring closure which may occur through benzyne or radical intermediates. Besides ortho halogenated dihydroanils and amides, the cyclisation of the benzylamine Schiff bases also provides a convenient route to isoquinoline alkaloids.
Volume 134, 2022
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