• Activation of α-sp3 centres toward electrophilic substitution in alcohols and amines

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    • Keywords


      Alpha-heterocarbanion; alpha-lithiation; protection; protection-activation; electrophilic substitution; alcohols; amines

    • Abstract


      The scope of electrophilic substitution at alpha-sp3 centres in alcohols and amines via their alpha-lithio species is reviewed. The importance of alpha-activation by the hetero atom protecting group is deliniated with special reference to transient protection-activation methodology.

    • Author Affiliations


      Alan R Katritzky1 Saumitra Sengupta1 2

      1. Department of Chemistry, University of Florida, Gainesville, FL - 32611, USA
      2. Department of Chemistry, University of California, Santa Barbara, CA - 93106, USA
    • Dates

  • Journal of Chemical Sciences | News

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