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    • Keywords


      Diazepam; polarography; cyclic voltammetry

    • Abstract


      The reduction of 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepine-2-one at the dropping mercury electrode has been investigated. The process is diffusion controlled; furthermore, the reduction wave enables the quantitative determination of the drug both in acid and basic media. The reagent captures two electrons and two hydrogen ions. A disproportionation reaction of the hydrazo-compound takes place, and amines are the final reduction products.

    • Author Affiliations


      L Thomas1 J L Vilchez1 G Crovetto2 J Thomas2

      1. Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Granada, Spain
      2. Department of Physics-Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain
    • Dates

  • Journal of Chemical Sciences | News

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