• Design and synthesis of systemically active enkephalin-like peptides

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    • Keywords


      Enkephalin analogues; analgesic activity; enzymatic deactivation; receptor-binding affinity; systemic administration

    • Abstract


      Following the discovery of enkephalins, it was observed that the mild analgesia evoked by them was completely dissipated within a few minutes even when they were injected directly into active brain sites. As these pentapeptides could serve as the prototypes of an entirely new class of analgesics, studies on their structure-function relationships were undertaken by a large number of investigators to get molecules which would produce profound and long-lasting analgesia even after systemic or oral administration. Various approaches that have helped in the successful achievement of this goal have been briefly reviewed.

    • Author Affiliations


      K B Mathur1

      1. Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow - 226001, India
    • Dates

  • Journal of Chemical Sciences | News

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