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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/093/05/0817-0830

    • Keywords

       

      Composite reaction; selection rule; transformation matrix; Onsager symmetry; entropy; thermodynamic equivalence

    • Abstract

       

      A composite reaction is represented by a number of elementary reactions describing its mechanisms. By a linear transformation, the chemical flow and flux can be changed and one might obtain a new mechanism. The present report works out the selection rule to be imposed on the transformation matrix if the two mechanisms are thermodynamically and/or, kinetically indistinguishable (or equivalent). The net free energy change, entropy production, Onsager symmetry, and the detailed balance condition are considered to be the invariants of the transformation for thermodynamic equivalence. The selection rule has to be slightly modified for cyclic reactions. Two cyclic reactions with equivalent mechanisms are also worked out. It is proposed that for biochemical systems predominated by cyclic reactions, the selection rule is more permissive, and occurrence of multiple mechanisms has a higher probability, resulting in an enhancement of the fidelity of the net reaction in the presence of random environmental ‘error variables’.

    • Author Affiliations

       

      Chitra Dutta1 Anjan Dasgupta1 Jyotirmoy Das1

      1. Biophysics Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Calcutta - 700 032, India
    • Dates

       
  • Journal of Chemical Sciences | News

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