• Peptides as bioorganic models

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      https://www.ias.ac.in/article/fulltext/jcsc/093/04/0703-0717

    • Keywords

       

      Peptide conformation; bioorganic models; alpha-aminoisobutyryl peptides; bacteriorhodopsin; bilirubin; gossypol; thioredoxin; peptide models

    • Abstract

       

      This article develops the possibility of using conformationally rigid peptides as bioorganic model systems. Stereochemical constraints on peptide backbone folding may be introduced by the judicious use of sequences containingα-aminoisobutyric acid and proline. The design of synthetic peptide models of 310-helical and β-turn conformations is reviewed. Attempts at generating model antiparallelβ-sheet peptides are discussed. The use of disulphide crosslinks is illustrated in the application of cystine peptides to generate models forβ-turn and antiparallelβ-sheet conformations. Using a conformationally well-defined backbone as a skeleton attempts to generate models for protein binding sites are examined. Helical retinylidene-lysine peptides are introduced as models for the bacteriorhodopsin chromophore. Lysine containing peptides and chiral diamines are explored as model-binding sites for bilirubin and gossypol. An attempt to model the active site disulphide loop of the redox protein, thioredoxin, is described.

    • Author Affiliations

       

      P Balaram1

      1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore - 560 012, India
    • Dates

       
  • Journal of Chemical Sciences | News

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