• A facile synthetic route to complex polycyclic natural products through intramolecular alkylation with α-diazomethyl ketones

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      https://www.ias.ac.in/article/fulltext/jcsc/093/04/0547-0563

    • Keywords

       

      α-diazomethyl ketones; intramolecular alkylation; α-ketocarbenoids; metalcatalysed reactions; acid-catalysed reaction; polycyclic synthesis

    • Abstract

       

      Some applications of the intramolecular alkylation of α-diazomethyl ketones through metal-catalysed addition and insertion reactions, and acid-catalysed olefinic and aryl participations, towards the synthesis of a variety of complex polycyclic natural products have been briefly reviewed with special emphasis on the results reported from the authors’ laboratories. The possible mechanisms of the transition metal catalysed carbon-carbon bond forming reactions of carbenoids have been briefly discussed in the light of the recent literature.

    • Author Affiliations

       

      Subrata Ghosh1 Usha Ranjan Ghatak1

      1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta - 700 032, India
    • Dates

       
  • Journal of Chemical Sciences | News

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