• Macromolecular crystallography research at Trombay

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/092/04-05/0497-0507

    • Keywords

       

      Protein crystallography; enzyme mechanism; neutron diffraction; x-ray diffraction; carbonic anhydrase; lysozyme; presynaptic toxins

    • Abstract

       

      Neutron diffraction studies of hydrogen positions in small molecules of biological interest at Trombay have provided valuable information that has been used in protein and enzyme structure model-building and in developing hydrogen bond potential functions. The new R-5 reactor is expected to provide higher neutron fluxes and also make possible smallangle neutron scattering studies of large biomolecules and bio-aggregates. In the last few years infrastructure facilities have also been established for macromolecular x-ray crystallography research. Meanwhile, the refinement of carbonic hydrases’ and lysozyme structures have been carried out and interesting results obtained on protein dynamics and structure-function relationships. Some interesting presynaptic toxin phospholipases have also been taken up for study.

    • Author Affiliations

       

      K K Kannan1 R Chidambaram1

      1. Neutron Physics Division, Bhabha Atomic Research Centre, Bombay - 400 085, India
    • Dates

       
  • Journal of Chemical Sciences | News

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