• Chiral synthesis of optically active S(+)-2,6,7,7a-tetrahydro-1β-hydroxy-4-formyl-7aβ-methylindene

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/092/02/0181-0187

    • Keywords

       

      Chiral synthesis; chemical resolution; optical rotatory dispersion; chiralnmr shift reagent

    • Abstract

       

      The chiral aldol cylization of the prochiral triketone 3 using l-valine afforded the optically active compound 4 in high chemical and optical yield. The configuration and optical purity of (+)4 was determined by ORD, chemical resolution andnmr chirallsr studies. The title compound (+)7 was prepared from (+)4 following our earlier reported procedure.

    • Author Affiliations

       

      D K Banerjee1 T R Kasturi1 A Sarkar1

      1. Department of Organic Chemistry, Indian Institute of Science, Bangalore - 560012, India
    • Dates

       
  • Journal of Chemical Sciences | News

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