Careful reaction of equimolar amounts of 1, 3-dichloroacetone and the amidinothioureas (4), (5), (6) or (10) has given the (2-amino-5-thiazolyl) chloromethyl ketones (7), (8), (9) and (11) respectively in 20 to 40% yields. The presence of excess amidinothiourea in the reaction mixture leads to the bis thiazolyl ketones (3).
Volume 135, 2023
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