• A general synthesis of thiazoles. Part 71. Direct generation of chloromethyl 5-thiazolyl ketones2

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      https://www.ias.ac.in/article/fulltext/jcsc/091/06/0457-0461

    • Keywords

       

      (2-amino-5-thiazolyl) chloromethyl ketones; direct synthesis; dichloroacetone; amidinothioureas

    • Abstract

       

      Careful reaction of equimolar amounts of 1, 3-dichloroacetone and the amidinothioureas (4), (5), (6) or (10) has given the (2-amino-5-thiazolyl) chloromethyl ketones (7), (8), (9) and (11) respectively in 20 to 40% yields. The presence of excess amidinothiourea in the reaction mixture leads to the bis thiazolyl ketones (3).

    • Author Affiliations

       

      S Rajappa1 V Sudarsanam2 R Sreenivasan1

      1. CIBA-Geigy Research Centre, Goregaon, Bombay - 400 063, India
      2. The Boots Company (India) Ltd., Sion, Bombay - 400 022, India
    • Dates

       
  • Journal of Chemical Sciences | News

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