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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/091/05/0445-0450

    • Keywords

       

      5-Acyl-2-dialkylaminothiazoles; 2-morpholinothiazole-5-carboxylic ester

    • Abstract

       

      Amidinothioureas (7), (11) and (12) obtained by condensation of N,N-disubstituted thioureas with amide acetals have been used as starting materials for the synthesis of thiazoles. Thus, reaction with chloracetone and phenacyl bromides leads to ketones; the use of chloracetic ester in this reaction yields the thiazole-5-carboxylic ester (10).

    • Author Affiliations

       

      S Rajappa1 V Sudarsanam2 B G Advani1 A V Rane1

      1. CIBA-GEIGY Research Centre, Goregaon, Bombay - 400 063, India
      2. The Boots Company (India) Ltd., SION, Bombay - 400 022, India
    • Dates

       
  • Journal of Chemical Sciences | News

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