• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/090/04/0291-0296

    • Keywords

       

      Furano benzopyrans synthesis; antifertility activity

    • Abstract

       

      Basic ethers, 2-phenyl-3-(p-β-dialkylaminoalkoxy)-phenyl 7(H) oxo furanocoumarin(VIa) and 9-methyl analog 2-phenyl-3-(p-β-dialkylaminoalkoxy)-phenyl-9-methyl 7(H) oxo furanocoumarin (VIb) have been synthesised by condensing 2-phenyl-3-p-hydroxyphenyl 7(H) oxo furanocoumarin (Va) and its 9-methyl analog (Vb) with appropriate β-tertiary aminoalkyl halide in acetone-potassium carbonate. Va and Vb were obtained by demethylating the methyl ethers IVa and IVb respectively with pyridine hydrochloride. IVa and IVb themselves were formed from the alkali-induced cyclisation of the ketones IIIa and IIIb. Among the compounds tested for antifertility activity, the basic ethers 12*, 14*, and 18* were found to have marked anti-implantation properties.

    • Author Affiliations

       

      B Rajitha1 Y Geetanjali1 M Kanakalingeswara Rao1 V V Somayajulu1 C K Atal2

      1. Department of Chemistry, Regional Engineering College, Warangal - 506 004, India
      2. Regional Research Laboratory, Jammu Tawi - 180 001, India
    • Dates

       
  • Journal of Chemical Sciences | News

© 2021-2022 Indian Academy of Sciences, Bengaluru.