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    • Keywords


      Furano benzopyrans synthesis; antifertility activity

    • Abstract


      Basic ethers, 2-phenyl-3-(p-β-dialkylaminoalkoxy)-phenyl 7(H) oxo furanocoumarin(VIa) and 9-methyl analog 2-phenyl-3-(p-β-dialkylaminoalkoxy)-phenyl-9-methyl 7(H) oxo furanocoumarin (VIb) have been synthesised by condensing 2-phenyl-3-p-hydroxyphenyl 7(H) oxo furanocoumarin (Va) and its 9-methyl analog (Vb) with appropriate β-tertiary aminoalkyl halide in acetone-potassium carbonate. Va and Vb were obtained by demethylating the methyl ethers IVa and IVb respectively with pyridine hydrochloride. IVa and IVb themselves were formed from the alkali-induced cyclisation of the ketones IIIa and IIIb. Among the compounds tested for antifertility activity, the basic ethers 12*, 14*, and 18* were found to have marked anti-implantation properties.

    • Author Affiliations


      B Rajitha1 Y Geetanjali1 M Kanakalingeswara Rao1 V V Somayajulu1 C K Atal2

      1. Department of Chemistry, Regional Engineering College, Warangal - 506 004, India
      2. Regional Research Laboratory, Jammu Tawi - 180 001, India
    • Dates

  • Journal of Chemical Sciences | News

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